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Abstract
Boczek, L.A.,
C.H. Johnson and E.W. Rice. 2004. Trimethoprim-sulfamethoxazole
resistance in sewage isolates of Escherichia coli. JEMREST 2:19-25
Sewage samples from seven
locations in the United
States were analyzed for Escherichia coli
isolates, which were resistant to the antibiotic trimethoprim-sulfamethoxazole
(TMP-SMX). The prevalence rate of TMP-SMX resistant organisms varied between
the different geographical locales. The majority of the TMP-SMX resistant E.
coli were also resistant to ampicillin and
tetracycline, and exhibited high maximum inhibitory concentration (MIC)
values. Resistant isolates were found in phylogenetic
groups associated with commensal E. coli (phylogenetic groups A and B1) as well as in those groups
associated with extraintestinal infections,
including urinary tract infections (UTIs) (phylogenetic groups B2 and D). Serogrouping
indicated that serogroups most often associated
with UTIs were found primarily in the B2 and D phylogenetic groupings. These findings suggest that commensal E. coli isolates may serve as a potential reservoir
of antibiotic resistance. Studies of sewage isolates conducted over time may
assist in determining indigenous levels of antibiotic resistance within a
community.
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